BDBM50174278 2-methoxy-5-(5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)-1,2,4-oxadiazol-3-yl)pyridine::CHEMBL426835

SMILES: COc1ccc(cn1)-c1noc(n1)C12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C

InChI Key: InChIKey=PTFSKFDIHUCRKB-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50174278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50174278 (2-methoxy-5-(5-(4-(4-methyl-5-(2-(trifluoromethyl)...) Show SMILES COc1ccc(cn1)-c1noc(n1)C12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C Show InChI InChI=1S/C26H25F3N6O2/c1-35-21(17-5-3-4-6-18(17)26(27,28)29)32-33-22(35)24-9-12-25(13-10-24,14-11-24)23-31-20(34-37-23)16-7-8-19(36-2)30-15-16/h3-8,15H,9-14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Inhibitory activity against mouse 11beta-HSD1				Bioorg Med Chem Lett 15: 5266-9 (2005) Article DOI: 10.1016/j.bmcl.2005.08.052 BindingDB Entry DOI: 10.7270/Q2QC031M
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50174278 (2-methoxy-5-(5-(4-(4-methyl-5-(2-(trifluoromethyl)...) Show SMILES COc1ccc(cn1)-c1noc(n1)C12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C Show InChI InChI=1S/C26H25F3N6O2/c1-35-21(17-5-3-4-6-18(17)26(27,28)29)32-33-22(35)24-9-12-25(13-10-24,14-11-24)23-31-20(34-37-23)16-7-8-19(36-2)30-15-16/h3-8,15H,9-14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.07	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD1				Bioorg Med Chem Lett 18: 2479-90 (2008) Article DOI: 10.1016/j.bmcl.2008.02.042 BindingDB Entry DOI: 10.7270/Q2QC04Q0
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50174278 (2-methoxy-5-(5-(4-(4-methyl-5-(2-(trifluoromethyl)...) Show SMILES COc1ccc(cn1)-c1noc(n1)C12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C Show InChI InChI=1S/C26H25F3N6O2/c1-35-21(17-5-3-4-6-18(17)26(27,28)29)32-33-22(35)24-9-12-25(13-10-24,14-11-24)23-31-20(34-37-23)16-7-8-19(36-2)30-15-16/h3-8,15H,9-14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Inhibitory activity against human 11beta-HSD1				Bioorg Med Chem Lett 15: 5266-9 (2005) Article DOI: 10.1016/j.bmcl.2005.08.052 BindingDB Entry DOI: 10.7270/Q2QC031M
					More data for this Ligand-Target Pair