BindingDB PrimarySearch

BDBM50174558 7-hydroxy-2H-1-benzopyran-2-one::7-hydroxy-2H-chromen-2-one::CHEMBL51628::Coumarin derivative, 3a::beta-umbelliferone::hydrangin::skimmetin::umbelliferone

SMILES: Oc1ccc2ccc(=O)oc2c1

InChI Key: InChIKey=ORHBXUUXSCNDEV-UHFFFAOYSA-N

Data: 16 KI 16 IC50

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50174558
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrases; II & IX (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Messina Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay				Eur J Med Chem 143: 276-282 (2018) Article DOI: 10.1016/j.ejmech.2017.11.061 BindingDB Entry DOI: 10.7270/Q2DZ0BVB
University of Messina Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Messina Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay				Eur J Med Chem 143: 276-282 (2018) Article DOI: 10.1016/j.ejmech.2017.11.061 BindingDB Entry DOI: 10.7270/Q2DZ0BVB
University of Messina Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	478	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier Curated by ChEMBL					Assay Description Inhibition of human recombinant CA9 after 6 hrs by stopped flow CO2 hydration assay				J Med Chem 54: 8271-7 (2011) Article DOI: 10.1021/jm200983e BindingDB Entry DOI: 10.7270/Q2KP82MQ
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 9 catalytic domain by Stopped-Flow CO2 Hydrase assay				J Med Chem 59: 462-73 (2016) BindingDB Entry DOI: 10.7270/Q2P2710K
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	482	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method				Bioorg Med Chem Lett 20: 7255-8 (2010) Article DOI: 10.1016/j.bmcl.2010.10.094 BindingDB Entry DOI: 10.7270/Q2416X9P
Università degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	750	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 12 catalytic domain by Stopped-Flow CO2 Hydrase assay				J Med Chem 59: 462-73 (2016) BindingDB Entry DOI: 10.7270/Q2P2710K
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Zn finger protein (Nicotiana tabacum)	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	754	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method				Bioorg Med Chem Lett 20: 7255-8 (2010) Article DOI: 10.1016/j.bmcl.2010.10.094 BindingDB Entry DOI: 10.7270/Q2416X9P
Università degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	754	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier Curated by ChEMBL					Assay Description Inhibition of human recombinant CA12 after 6 hrs by stopped flow CO2 hydration assay				J Med Chem 54: 8271-7 (2011) Article DOI: 10.1021/jm200983e BindingDB Entry DOI: 10.7270/Q2KP82MQ
					More data for this Ligand-Target Pair
Carbonic anhydrase (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Messina Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay				Eur J Med Chem 143: 276-282 (2018) Article DOI: 10.1016/j.ejmech.2017.11.061 BindingDB Entry DOI: 10.7270/Q2DZ0BVB
University of Messina Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Messina Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay				Eur J Med Chem 143: 276-282 (2018) Article DOI: 10.1016/j.ejmech.2017.11.061 BindingDB Entry DOI: 10.7270/Q2DZ0BVB
University of Messina Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.84E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of full length human CA1 cytosolic isoform by stopped-flow CO2 hydration method				Bioorg Med Chem Lett 20: 7255-8 (2010) Article DOI: 10.1016/j.bmcl.2010.10.094 BindingDB Entry DOI: 10.7270/Q2416X9P
Università degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	5.84E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assay				J Med Chem 59: 462-73 (2016) BindingDB Entry DOI: 10.7270/Q2P2710K
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.84E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier Curated by ChEMBL					Assay Description Inhibition of human full-length cytosolic CA1 after 6 hrs by stopped flow CO2 hydration assay				J Med Chem 54: 8271-7 (2011) Article DOI: 10.1021/jm200983e BindingDB Entry DOI: 10.7270/Q2KP82MQ
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of full length human CA2 cytosolic isoform by stopped-flow CO2 hydration method				Bioorg Med Chem Lett 20: 7255-8 (2010) Article DOI: 10.1016/j.bmcl.2010.10.094 BindingDB Entry DOI: 10.7270/Q2416X9P
Università degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier Curated by ChEMBL					Assay Description Inhibition of human full-length cytosolic CA2 after 6 hrs by stopped flow CO2 hydration assay				J Med Chem 54: 8271-7 (2011) Article DOI: 10.1021/jm200983e BindingDB Entry DOI: 10.7270/Q2KP82MQ
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 2 by Stopped-Flow CO2 Hydrase assay				J Med Chem 59: 462-73 (2016) BindingDB Entry DOI: 10.7270/Q2P2710K
Universit£ degli Studi di Firenze Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (fumarate) (Leishmania major)	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.67E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of S£o Paulo Curated by ChEMBL					Assay Description Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...				Eur J Med Chem 157: 852-866 (2018) Article DOI: 10.1016/j.ejmech.2018.08.033 BindingDB Entry DOI: 10.7270/Q2FJ2KFS
University of S£o Paulo Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (fumarate) (Leishmania major)	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.01E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of S£o Paulo Curated by ChEMBL					Assay Description Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...				Eur J Med Chem 157: 852-866 (2018) Article DOI: 10.1016/j.ejmech.2018.08.033 BindingDB Entry DOI: 10.7270/Q2FJ2KFS
University of S£o Paulo Curated by ChEMBL					More data for this Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase liver (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.17E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de Minas Gerais Curated by ChEMBL					Assay Description Inhibitory concentration against glyceraldehyde-3-phosphate dehydrogenase was determined as log 1/IC50				Bioorg Med Chem Lett 14: 2199-204 (2004) Article DOI: 10.1016/j.bmcl.2004.02.025 BindingDB Entry DOI: 10.7270/Q20K2810
Universidade Federal de Minas Gerais Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.90E+7	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of AChE by spectrophotometry				J Nat Prod 64: 683-5 (2001) BindingDB Entry DOI: 10.7270/Q29G5NQD
Seoul National University Curated by ChEMBL					More data for this Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal (Trypanosoma cruzi)	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.17E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de S£o Paulo Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi recombinant glycosomal GAPDH expressed in Escherichia coli by spectrophotometry				Bioorg Med Chem 17: 2476-82 (2009) Article DOI: 10.1016/j.bmc.2009.01.079 BindingDB Entry DOI: 10.7270/Q2BC40FV
Universidade de S£o Paulo Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Electrophorus electricus (Electric eel))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to 180...				Eur J Med Chem 64: 540-53 (2013) Article DOI: 10.1016/j.ejmech.2013.03.051 BindingDB Entry DOI: 10.7270/Q2H996KW
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Butyrylcholinesterase (BuChE) (Equus caballus (Horse))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of equine serum BChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to ...				Eur J Med Chem 64: 540-53 (2013) Article DOI: 10.1016/j.ejmech.2013.03.051 BindingDB Entry DOI: 10.7270/Q2H996KW
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Steroid 5-alpha-reductase (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>20	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibitory activity against 5-alpha-reductase type 1 in cell culture system using LNCaP cells (androgen-sensitive human prostatic cancer cell line)				Bioorg Med Chem Lett 11: 2361-3 (2001) BindingDB Entry DOI: 10.7270/Q2RR1ZS9
Seoul National University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Santiago de Compostela Curated by ChEMBL					Assay Description Inhibition of tyrosinase				Bioorg Med Chem Lett 21: 3342-5 (2011) Article DOI: 10.1016/j.bmcl.2011.04.012 BindingDB Entry DOI: 10.7270/Q2QF8T68
Universidad de Santiago de Compostela Curated by ChEMBL					More data for this Ligand-Target Pair
Sorbitol dehydrogenase (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Toyama Curated by ChEMBL					Assay Description Inhibition sorbitol dehydrogenase by spectrophotometric analysis				Bioorg Med Chem Lett 20: 5630-3 (2010) Article DOI: 10.1016/j.bmcl.2010.08.038 BindingDB Entry DOI: 10.7270/Q28052TK
University of Toyama Curated by ChEMBL					More data for this Ligand-Target Pair
Aldose reductase (AR) (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Toyama Curated by ChEMBL					Assay Description Inhibition human recombinant aldose reductase 1 by spectrophotometric analysis				Bioorg Med Chem Lett 20: 5630-3 (2010) Article DOI: 10.1016/j.bmcl.2010.08.038 BindingDB Entry DOI: 10.7270/Q28052TK
University of Toyama Curated by ChEMBL					More data for this Ligand-Target Pair
Xanthine dehydrogenase/oxidase (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.36E+5	n/a	n/a	n/a	n/a	n/a	n/a
Università di Modena e Reggio Emilia Curated by ChEMBL					Assay Description Inhibition of xanthine oxidase				Eur J Med Chem 42: 1028-31 (2007) Article DOI: 10.1016/j.ejmech.2006.12.023 BindingDB Entry DOI: 10.7270/Q2DR2V58
Università di Modena e Reggio Emilia Curated by ChEMBL					More data for this Ligand-Target Pair
Lipoxygenase-1 (Glycine max (soybean))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Inhibitory concentration against soybean lipoxygenase upon incubation with sodium linoleate (0.1 mM) at RT				J Med Chem 48: 6400-8 (2005) Article DOI: 10.1021/jm0580149 BindingDB Entry DOI: 10.7270/Q2JM295H
Aristotle University of Thessaloniki Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Monastir Curated by ChEMBL					Assay Description Inhibition of acetylcholinesterase (unknown origin) using acetylcholine iodide as substrate preincubated for 15 mins prior to substrate addition by s...				Bioorg Med Chem Lett 23: 4248-52 (2013) Article DOI: 10.1016/j.bmcl.2013.04.081 BindingDB Entry DOI: 10.7270/Q29W0JCX
University of Monastir Curated by ChEMBL					More data for this Ligand-Target Pair
Non-structural protein 5B (NS5B) (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.66E+4	n/a	n/a	n/a	n/a	7.0	30
UMDNJ-New Jersey Medical School					Assay Description Inhibition assay using HCV NS5B.				Chem Biol Drug Des 81: 607-14 (2013) Article DOI: 10.1111/cbdd.12105 BindingDB Entry DOI: 10.7270/Q2R78CT6
UMDNJ-New Jersey Medical School					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM50174558 (7-hydroxy-2H-1-benzopyran-2-one \| 7-hydroxy-2H-chr...) Show SMILES Oc1ccc2ccc(=O)oc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Kinki University Curated by ChEMBL					Assay Description Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins by fluorescence quenching assay				Bioorg Med Chem 20: 784-8 (2012) Article DOI: 10.1016/j.bmc.2011.12.002 BindingDB Entry DOI: 10.7270/Q2F47PKK
Kinki University Curated by ChEMBL					More data for this Ligand-Target Pair