BDBM50174687 CHEMBL202926::N-[5-(10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-ylamino)-pyrimidin-2-yl]-4-methyl-benzamide

SMILES: Cc1ccc(cc1)C(=O)Nc1ncc(Nc2ncnc3Oc4ccccc4CNc23)cn1

InChI Key: InChIKey=BJOYZCHWZJWIDO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50174687   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM50174687 (CHEMBL202926 | N-[5-(10,11-dihydro-5-oxa-2,4,11-tr...) Show SMILES Cc1ccc(cc1)C(=O)Nc1ncc(Nc2ncnc3Oc4ccccc4CNc23)cn1 Show InChI InChI=1S/C23H19N7O2/c1-14-6-8-15(9-7-14)21(31)30-23-25-11-17(12-26-23)29-20-19-22(28-13-27-20)32-18-5-3-2-4-16(18)10-24-19/h2-9,11-13,24H,10H2,1H3,(H,27,28,29)(H,25,26,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
ImClone Systems Inc Curated by ChEMBL					Assay Description Inhibitory activity against Aurora A kinase				Bioorg Med Chem Lett 15: 5474-7 (2005) Article DOI: 10.1016/j.bmcl.2005.08.098 BindingDB Entry DOI: 10.7270/Q2S46RGS
					More data for this Ligand-Target Pair