BDBM50175316 6-(4-chlorophenyl)-3-(2-(4-(2-chlorophenyl)piperazin-1-yl)ethyl)-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione::CHEMBL199876

SMILES: Clc1ccc(cc1)-c1cc2c([nH]1)[nH]c(=O)n(CCN1CCN(CC1)c1ccccc1Cl)c2=O

InChI Key: InChIKey=XRHMVCVKZQLVNP-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50175316   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50175316 (6-(4-chlorophenyl)-3-(2-(4-(2-chlorophenyl)piperaz...) Show SMILES Clc1ccc(cc1)-c1cc2c([nH]1)[nH]c(=O)n(CCN1CCN(CC1)c1ccccc1Cl)c2=O Show InChI InChI=1S/C24H23Cl2N5O2/c25-17-7-5-16(6-8-17)20-15-18-22(27-20)28-24(33)31(23(18)32)14-11-29-9-12-30(13-10-29)21-4-2-1-3-19(21)26/h1-8,15,27H,9-14H2,(H,28,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	544	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università di Catania Curated by ChEMBL					Assay Description Binding affinity to dopamine D1 receptor				Bioorg Med Chem Lett 16: 150-3 (2005) Article DOI: 10.1016/j.bmcl.2005.09.027 BindingDB Entry DOI: 10.7270/Q2571BJ8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50175316 (6-(4-chlorophenyl)-3-(2-(4-(2-chlorophenyl)piperaz...) Show SMILES Clc1ccc(cc1)-c1cc2c([nH]1)[nH]c(=O)n(CCN1CCN(CC1)c1ccccc1Cl)c2=O Show InChI InChI=1S/C24H23Cl2N5O2/c25-17-7-5-16(6-8-17)20-15-18-22(27-20)28-24(33)31(23(18)32)14-11-29-9-12-30(13-10-29)21-4-2-1-3-19(21)26/h1-8,15,27H,9-14H2,(H,28,33)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.51E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università di Catania Curated by ChEMBL					Assay Description Binding affinity to 5HT1A				Bioorg Med Chem Lett 16: 150-3 (2005) Article DOI: 10.1016/j.bmcl.2005.09.027 BindingDB Entry DOI: 10.7270/Q2571BJ8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50175316 (6-(4-chlorophenyl)-3-(2-(4-(2-chlorophenyl)piperaz...) Show SMILES Clc1ccc(cc1)-c1cc2c([nH]1)[nH]c(=O)n(CCN1CCN(CC1)c1ccccc1Cl)c2=O Show InChI InChI=1S/C24H23Cl2N5O2/c25-17-7-5-16(6-8-17)20-15-18-22(27-20)28-24(33)31(23(18)32)14-11-29-9-12-30(13-10-29)21-4-2-1-3-19(21)26/h1-8,15,27H,9-14H2,(H,28,33)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.51E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Catania Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5HT1A in CRL:CD(SD)BR-COBS rat brain hippocampus after 30 mins by liquid scintillation spectrometry				Bioorg Med Chem 19: 5260-76 (2011) Article DOI: 10.1016/j.bmc.2011.06.043 BindingDB Entry DOI: 10.7270/Q2D50NBD
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50175316 (6-(4-chlorophenyl)-3-(2-(4-(2-chlorophenyl)piperaz...) Show SMILES Clc1ccc(cc1)-c1cc2c([nH]1)[nH]c(=O)n(CCN1CCN(CC1)c1ccccc1Cl)c2=O Show InChI InChI=1S/C24H23Cl2N5O2/c25-17-7-5-16(6-8-17)20-15-18-22(27-20)28-24(33)31(23(18)32)14-11-29-9-12-30(13-10-29)21-4-2-1-3-19(21)26/h1-8,15,27H,9-14H2,(H,28,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.37E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università di Catania Curated by ChEMBL					Assay Description Binding affinity to dopamine D2 receptor				Bioorg Med Chem Lett 16: 150-3 (2005) Article DOI: 10.1016/j.bmcl.2005.09.027 BindingDB Entry DOI: 10.7270/Q2571BJ8
					More data for this Ligand-Target Pair