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BDBM50175374 (R)-2-chloro-6-(2-hydroxy-3-(methyl(2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile::CHEMBL370811

SMILES: CN(C[C@@H](O)COc1cccc(Cl)c1C#N)C(C)(C)Cc1ccc2ccccc2c1

InChI Key: InChIKey=ONQBSDHBBICEQE-OAQYLSRUSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50175374   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))		BDBM50175374
PNG
((R)-2-chloro-6-(2-hydroxy-3-(methyl(2-methyl-1-(na...)
Show SMILES CN(C[C@@H](O)COc1cccc(Cl)c1C#N)C(C)(C)Cc1ccc2ccccc2c1
Show InChI InChI=1S/C25H27ClN2O2/c1-25(2,14-18-11-12-19-7-4-5-8-20(19)13-18)28(3)16-21(29)17-30-24-10-6-9-23(26)22(24)15-27/h4-13,21,29H,14,16-17H2,1-3H3/t21-/m1/s1
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Article
PubMed
n/an/a 270n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR

Bioorg Med Chem Lett 15: 5478-82 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.095
BindingDB Entry DOI: 10.7270/Q2WS8STX
More data for this
Ligand-Target Pair