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BDBM50175736 4-(1-benzoyl-1H-imidazol-2-yl)-N,4-diphenylpiperidine-1-carboxamide::CHEMBL199545

SMILES: O=C(Nc1ccccc1)N1CCC(CC1)(c1nccn1C(=O)c1ccccc1)c1ccccc1

InChI Key: InChIKey=VTILWSFMCMCFSG-UHFFFAOYSA-N

Data: 3 KI

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50175736   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50175736
PNG
(4-(1-benzoyl-1H-imidazol-2-yl)-N,4-diphenylpiperid...)
Show SMILES O=C(Nc1ccccc1)N1CCC(CC1)(c1nccn1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H26N4O2/c33-25(22-10-4-1-5-11-22)32-21-18-29-26(32)28(23-12-6-2-7-13-23)16-19-31(20-17-28)27(34)30-24-14-8-3-9-15-24/h1-15,18,21H,16-17,19-20H2,(H,30,34)
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.19E+3n/an/an/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]U-69593 from cloned human kappa opioid receptor


Bioorg Med Chem Lett 16: 146-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.025
BindingDB Entry DOI: 10.7270/Q2ZK5G70
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50175736
PNG
(4-(1-benzoyl-1H-imidazol-2-yl)-N,4-diphenylpiperid...)
Show SMILES O=C(Nc1ccccc1)N1CCC(CC1)(c1nccn1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H26N4O2/c33-25(22-10-4-1-5-11-22)32-21-18-29-26(32)28(23-12-6-2-7-13-23)16-19-31(20-17-28)27(34)30-24-14-8-3-9-15-24/h1-15,18,21H,16-17,19-20H2,(H,30,34)
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Article
PubMed
3.70E+3n/an/an/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]DPDPE from cloned human delta opioid receptor


Bioorg Med Chem Lett 16: 146-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.025
BindingDB Entry DOI: 10.7270/Q2ZK5G70
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50175736
PNG
(4-(1-benzoyl-1H-imidazol-2-yl)-N,4-diphenylpiperid...)
Show SMILES O=C(Nc1ccccc1)N1CCC(CC1)(c1nccn1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H26N4O2/c33-25(22-10-4-1-5-11-22)32-21-18-29-26(32)28(23-12-6-2-7-13-23)16-19-31(20-17-28)27(34)30-24-14-8-3-9-15-24/h1-15,18,21H,16-17,19-20H2,(H,30,34)
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PubMed
>4.65E+3n/an/an/an/an/an/an/an/a



Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from cloned human mu opioid receptor


Bioorg Med Chem Lett 16: 146-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.025
BindingDB Entry DOI: 10.7270/Q2ZK5G70
More data for this
Ligand-Target Pair