BDBM50175900 8-[(1S,2S)-2-(4-fluoro-phenyl)-cyclohexyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL199888
SMILES: Fc1ccc(cc1)[C@@H]1CCCC[C@@H]1N1CCC2(CC1)N(CNC2=O)c1ccccc1
InChI Key: InChIKey=VGBQPBWCRFVQJM-GOTSBHOMSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glycine transporter 2 (Homo sapiens (Human)) | BDBM50175900 (8-[(1S,2S)-2-(4-fluoro-phenyl)-cyclohexyl]-1-pheny...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake in cells transfected with human GlyT2 cDNA | Bioorg Med Chem Lett 16: 349-53 (2005) Article DOI: 10.1016/j.bmcl.2005.09.075 BindingDB Entry DOI: 10.7270/Q2XK8F42 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycine transporter 1 (Homo sapiens (Human)) | BDBM50175900 (8-[(1S,2S)-2-(4-fluoro-phenyl)-cyclohexyl]-1-pheny...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake in cells transfected with human GlyT1 cDNA | Bioorg Med Chem Lett 16: 349-53 (2005) Article DOI: 10.1016/j.bmcl.2005.09.075 BindingDB Entry DOI: 10.7270/Q2XK8F42 | |||||||||||
More data for this Ligand-Target Pair |