BDBM50175941 8-((cis, rac)-2-hydroxy-2-pyridin-3-yl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL200695

SMILES: O[C@]1(CCCC[C@H]1N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccnc1

InChI Key: InChIKey=DQALBJZNLDLJRD-ZJSXRUAMSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50175941   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycine transporter 1 (Homo sapiens (Human))	BDBM50175941 (8-((cis, rac)-2-hydroxy-2-pyridin-3-yl-cyclohexyl)...) Show SMILES O[C@]1(CCCC[C@H]1N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccnc1 Show InChI InChI=1S/C24H30N4O2/c29-22-23(28(18-26-22)20-8-2-1-3-9-20)12-15-27(16-13-23)21-10-4-5-11-24(21,30)19-7-6-14-25-17-19/h1-3,6-9,14,17,21,30H,4-5,10-13,15-16,18H2,(H,26,29)/t21-,24-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Displacement of [3H]glycine from human GlyT1 by radiometric assay				Bioorg Med Chem Lett 16: 354-7 (2005) Article DOI: 10.1016/j.bmcl.2005.09.067 BindingDB Entry DOI: 10.7270/Q2P26XPX
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50175941 (8-((cis, rac)-2-hydroxy-2-pyridin-3-yl-cyclohexyl)...) Show SMILES O[C@]1(CCCC[C@H]1N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccnc1 Show InChI InChI=1S/C24H30N4O2/c29-22-23(28(18-26-22)20-8-2-1-3-9-20)12-15-27(16-13-23)21-10-4-5-11-24(21,30)19-7-6-14-25-17-19/h1-3,6-9,14,17,21,30H,4-5,10-13,15-16,18H2,(H,26,29)/t21-,24-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.34E+4	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Displacement of [3H]NOP from human NOP receptor expressed in HEK293 cells				Bioorg Med Chem Lett 16: 354-7 (2005) Article DOI: 10.1016/j.bmcl.2005.09.067 BindingDB Entry DOI: 10.7270/Q2P26XPX
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50175941 (8-((cis, rac)-2-hydroxy-2-pyridin-3-yl-cyclohexyl)...) Show SMILES O[C@]1(CCCC[C@H]1N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cccnc1 Show InChI InChI=1S/C24H30N4O2/c29-22-23(28(18-26-22)20-8-2-1-3-9-20)12-15-27(16-13-23)21-10-4-5-11-24(21,30)19-7-6-14-25-17-19/h1-3,6-9,14,17,21,30H,4-5,10-13,15-16,18H2,(H,26,29)/t21-,24-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Inhibitory activity at human mu opioid receptor in BHK cells by GTPgammaS binding assay				Bioorg Med Chem Lett 16: 354-7 (2005) Article DOI: 10.1016/j.bmcl.2005.09.067 BindingDB Entry DOI: 10.7270/Q2P26XPX
					More data for this Ligand-Target Pair