null

SMILES: CC(C)(CNC(=O)Nc1ccc(Cl)cc1)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1

InChI Key: InChIKey=PQMASEVATAUGTO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50176323   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50176323 (1-(2-(4-(4-chloro-3-hydroxyphenyl)-5-(pyridin-4-yl...) Show SMILES CC(C)(CNC(=O)Nc1ccc(Cl)cc1)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 Show InChI InChI=1S/C25H23Cl2N5O2/c1-25(2,14-29-24(34)30-18-6-4-17(26)5-7-18)23-31-21(15-9-11-28-12-10-15)22(32-23)16-3-8-19(27)20(33)13-16/h3-13,33H,14H2,1-2H3,(H,31,32)(H2,29,30,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity at bRaf kinase in fluorescent ligand displacement assay				Bioorg Med Chem Lett 16: 378-81 (2005) Article DOI: 10.1016/j.bmcl.2005.09.072 BindingDB Entry DOI: 10.7270/Q2Z038Z9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50176323 (1-(2-(4-(4-chloro-3-hydroxyphenyl)-5-(pyridin-4-yl...) Show SMILES CC(C)(CNC(=O)Nc1ccc(Cl)cc1)c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1 Show InChI InChI=1S/C25H23Cl2N5O2/c1-25(2,14-29-24(34)30-18-6-4-17(26)5-7-18)23-31-21(15-9-11-28-12-10-15)22(32-23)16-3-8-19(27)20(33)13-16/h3-13,33H,14H2,1-2H3,(H,31,32)(H2,29,30,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition bRaf kinase activity				Bioorg Med Chem Lett 16: 378-81 (2005) Article DOI: 10.1016/j.bmcl.2005.09.072 BindingDB Entry DOI: 10.7270/Q2Z038Z9
					More data for this Ligand-Target Pair