BindingDB PrimarySearch

BDBM50176521 5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-carboxylic acid [1,3,4]thiadiazol-2-ylamide::CHEMBL200906

SMILES: CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12

InChI Key: InChIKey=OQMLSKSSPKAKJQ-UHFFFAOYSA-N

Data: 13 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50176521
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE1 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE3 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE5 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 11A (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE11 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE10 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE4C by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 8 (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE8B by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 8 (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE8A by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE4B by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE4A by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE2 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphodiesterase 9A (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE9 by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50176521 (5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...) Show SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against PDE4D by scintillation proximity assay				Bioorg Med Chem Lett 16: 307-10 (2005) Article DOI: 10.1016/j.bmcl.2005.10.005 BindingDB Entry DOI: 10.7270/Q2XD118H
Pfizer, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair