| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Ligand | BDBM50176521 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_327540 (CHEMBL854355) |
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| IC50 | >16000±n/a nM |
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| Citation |  Chambers, RJ; Abrams, K; Garceau, NY; Kamath, AV; Manley, CM; Lilley, SC; Otte, DA; Scott, DO; Sheils, AL; Tess, DA; Vellekoop, AS; Zhang, Y; Lam, KT A new chemical tool for exploring the physiological function of the PDE2 isozyme. Bioorg Med Chem Lett16:307-10 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE1 | NP_000914.2 | PDE21 | PDE4C | PDE4C1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 79875.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08493 |
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| Residue: | 712 |
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| Sequence: | MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERD
LSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESF
LYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGA
AKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRI
LNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSA
SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL
KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA
ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL
SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN
LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF
IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL
TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
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| BDBM50176521 |
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| n/a |
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| Name | BDBM50176521 |
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| Synonyms: | 5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-carboxylic acid [1,3,4]thiadiazol-2-ylamide | CHEMBL200906 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10N4O3S |
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| Mol. Mass. | 314.319 |
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| SMILES | CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12 |
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| Structure | 
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