BDBM50177093 9-Dimethylamino-3-(4-ethyl-phenyl)-2-methyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one::9-dimethylamino-2-methyl-3H-5-thia-1,3,6-triazafluoren-4-one::CHEMBL224673

SMILES: CCc1ccc(cc1)-n1c(C)nc2c(sc3nccc(N(C)C)c23)c1=O

InChI Key: InChIKey=GRTPVLUWVUWRRC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50177093   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50177093 (9-Dimethylamino-3-(4-ethyl-phenyl)-2-methyl-3H-pyr...) Show SMILES CCc1ccc(cc1)-n1c(C)nc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C20H20N4OS/c1-5-13-6-8-14(9-7-13)24-12(2)22-17-16-15(23(3)4)10-11-21-19(16)26-18(17)20(24)25/h6-11H,5H2,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization				J Med Chem 48: 7374-88 (2005) Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50177093 (9-Dimethylamino-3-(4-ethyl-phenyl)-2-methyl-3H-pyr...) Show SMILES CCc1ccc(cc1)-n1c(C)nc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C20H20N4OS/c1-5-13-6-8-14(9-7-13)24-12(2)22-17-16-15(23(3)4)10-11-21-19(16)26-18(17)20(24)25/h6-11H,5H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Biocampus Curated by ChEMBL					Assay Description Inhibition of rat mGluR1				Eur J Med Chem 43: 1025-34 (2008) Article DOI: 10.1016/j.ejmech.2007.06.024 BindingDB Entry DOI: 10.7270/Q2V987VM
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50177093 (9-Dimethylamino-3-(4-ethyl-phenyl)-2-methyl-3H-pyr...) Show SMILES CCc1ccc(cc1)-n1c(C)nc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C20H20N4OS/c1-5-13-6-8-14(9-7-13)24-12(2)22-17-16-15(23(3)4)10-11-21-19(16)26-18(17)20(24)25/h6-11H,5H2,1-4H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	344	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human mGluR5 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilization				J Med Chem 48: 7374-88 (2005) Article DOI: 10.1021/jm0504407 BindingDB Entry DOI: 10.7270/Q27P8XX0
					More data for this Ligand-Target Pair