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SMILES: Cc1noc(C)c1CNC(=O)C1CN(CCN1C(=O)NC1CCCCC1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12

InChI Key: InChIKey=XJLKHBJYSDKRSX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50177260   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50177260
PNG
(4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...)
Show SMILES Cc1noc(C)c1CNC(=O)C1CN(CCN1C(=O)NC1CCCCC1)C1c2ccc(Cl)cc2CCc2cc(Br)cnc12
Show InChI InChI=1S/C32H38BrClN6O3/c1-19-27(20(2)43-38-19)17-36-31(41)28-18-39(12-13-40(28)32(42)37-25-6-4-3-5-7-25)30-26-11-10-24(34)15-21(26)8-9-22-14-23(33)16-35-29(22)30/h10-11,14-16,25,28,30H,3-9,12-13,17-18H2,1-2H3,(H,36,41)(H,37,42)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 760n/an/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase quantified by SPA assay

Bioorg Med Chem Lett 16: 507-11 (2005)


Article DOI: 10.1016/j.bmcl.2005.10.070
BindingDB Entry DOI: 10.7270/Q2M0450S
More data for this
Ligand-Target Pair