BDBM50177440 4-(3-(1-cyclohexyl-1,4-diazepane-4-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one::CHEMBL204348
SMILES: Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCCN(CC1)C1CCCCC1
InChI Key: InChIKey=CQEXDWGGRJLLLQ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM50177440 (4-(3-(1-cyclohexyl-1,4-diazepane-4-carbonyl)-4-flu...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
KuDOS Pharmaceuticals Ltd Curated by ChEMBL | Assay Description Inhibitory activity against PARP1 | Bioorg Med Chem Lett 16: 1040-4 (2006) Article DOI: 10.1016/j.bmcl.2005.10.081 BindingDB Entry DOI: 10.7270/Q25T3K12 | |||||||||||
More data for this Ligand-Target Pair |