BDBM50177725 CHEMBL3815134

SMILES: CNC(=O)Cn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)-c2c1

InChI Key: InChIKey=GPLUYLMQYLVCDG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50177725   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177725 (CHEMBL3815134) Show SMILES CNC(=O)Cn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)-c2c1 Show InChI InChI=1S/C22H15N5O2/c1-24-19(28)11-27-10-14(9-25-27)13-3-5-15-17(7-13)21-20(22(15)29)16-4-2-12(8-23)6-18(16)26-21/h2-7,9-10,26H,11H2,1H3,(H,24,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo...				ACS Med Chem Lett 7: 476-81 (2016) BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50177725 (CHEMBL3815134) Show SMILES CNC(=O)Cn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)C#N)-c2c1 Show InChI InChI=1S/C22H15N5O2/c1-24-19(28)11-27-10-14(9-25-27)13-3-5-15-17(7-13)21-20(22(15)29)16-4-2-12(8-23)6-18(16)26-21/h2-7,9-10,26H,11H2,1H3,(H,24,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer g...				ACS Med Chem Lett 7: 476-81 (2016) BindingDB Entry DOI: 10.7270/Q2HD7XJD
					More data for this Ligand-Target Pair