BDBM50177817 2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]amino}-5-[(penta fluorobenzyl)oxy]benzo-1,4-quinone::CHEMBL370356

SMILES: COc1cc2c(N=C3CC(=O)C(OCc4c(F)c(F)c(F)c(F)c4F)=CC3=O)ncnc2cc1OCCCN1CCCC1

InChI Key: InChIKey=OUZYELZMZNWQIY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50177817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50177817 (2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...) Show SMILES COc1cc2c(N=C3CC(=O)C(OCc4c(F)c(F)c(F)c(F)c4F)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:25| Show InChI InChI=1S/C29H25F5N4O5/c1-41-22-9-15-17(11-23(22)42-8-4-7-38-5-2-3-6-38)35-14-36-29(15)37-18-10-20(40)21(12-19(18)39)43-13-16-24(30)26(32)28(34)27(33)25(16)31/h9,11-12,14H,2-8,10,13H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione				J Med Chem 48: 7560-81 (2005) Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50177817 (2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...) Show SMILES COc1cc2c(N=C3CC(=O)C(OCc4c(F)c(F)c(F)c(F)c4F)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:25| Show InChI InChI=1S/C29H25F5N4O5/c1-41-22-9-15-17(11-23(22)42-8-4-7-38-5-2-3-6-38)35-14-36-29(15)37-18-10-20(40)21(12-19(18)39)43-13-16-24(30)26(32)28(34)27(33)25(16)31/h9,11-12,14H,2-8,10,13H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione				J Med Chem 48: 7560-81 (2005) Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50177817 (2-{[6-Methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazol...) Show SMILES COc1cc2c(N=C3CC(=O)C(OCc4c(F)c(F)c(F)c(F)c4F)=CC3=O)ncnc2cc1OCCCN1CCCC1 |w:6.5,c:25| Show InChI InChI=1S/C29H25F5N4O5/c1-41-22-9-15-17(11-23(22)42-8-4-7-38-5-2-3-6-38)35-14-36-29(15)37-18-10-20(40)21(12-19(18)39)43-13-16-24(30)26(32)28(34)27(33)25(16)31/h9,11-12,14H,2-8,10,13H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma				J Med Chem 48: 7560-81 (2005) Article DOI: 10.1021/jm050559f BindingDB Entry DOI: 10.7270/Q2028R3S
					More data for this Ligand-Target Pair