BDBM50178881 9-cyclopropyl-7-(2,6-dimethoxypyridin-3-yl)-6-fluoroisothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione::CHEMBL206553

SMILES: COc1ccc(c(OC)n1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F

InChI Key: InChIKey=QSZTVRPKJCEKPM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50178881   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Topoisomerase IV subunit A (Staphylococcus aureus)	BDBM50178881 (9-cyclopropyl-7-(2,6-dimethoxypyridin-3-yl)-6-fluo...) Show SMILES COc1ccc(c(OC)n1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C20H16FN3O4S/c1-27-15-6-5-10(19(22-15)28-2)11-8-14-12(7-13(11)21)17(25)16-18(26)23-29-20(16)24(14)9-3-4-9/h5-9H,3-4H2,1-2H3,(H,23,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair