BDBM50178908 9-cyclopropyl-6-fluoro-7-(5-methylpyridin-2-yl)isothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione::CHEMBL378608

SMILES: Cc1ccc(nc1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F

InChI Key: InChIKey=YCKPHBNFZOGCBJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50178908   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178908 (9-cyclopropyl-6-fluoro-7-(5-methylpyridin-2-yl)iso...) Show SMILES Cc1ccc(nc1)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C19H14FN3O2S/c1-9-2-5-14(21-8-9)11-7-15-12(6-13(11)20)17(24)16-18(25)22-26-19(16)23(15)10-3-4-10/h2,5-8,10H,3-4H2,1H3,(H,22,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair