BDBM50178909 9-cyclopropyl-6-fluoro-7-(1-methyl-1H-indol-5-yl)isothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione::CHEMBL204544

SMILES: Cn1ccc2cc(ccc12)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F

InChI Key: InChIKey=TZFRJVUHUNQRGD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50178909   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 4 subunit A (Staphylococcus aureus)	BDBM50178909 (9-cyclopropyl-6-fluoro-7-(1-methyl-1H-indol-5-yl)i...) Show SMILES Cn1ccc2cc(ccc12)-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F Show InChI InChI=1S/C22H16FN3O2S/c1-25-7-6-12-8-11(2-5-17(12)25)14-10-18-15(9-16(14)23)20(27)19-21(28)24-29-22(19)26(18)13-3-4-13/h2,5-10,13H,3-4H2,1H3,(H,24,28)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Achillion Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4				Bioorg Med Chem Lett 16: 1277-81 (2006) Article DOI: 10.1016/j.bmcl.2005.11.064 BindingDB Entry DOI: 10.7270/Q26D5SKN
					More data for this Ligand-Target Pair