BindingDB logo
myBDB logout

null

SMILES: Fc1cc2c(cc1-c1cnccn1)n(C1CC1)c1s[nH]c(=O)c1c2=O

InChI Key: InChIKey=VGXSEFMYPYGXAQ-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50178911   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 4 subunit A


(Staphylococcus aureus)		BDBM50178911
PNG
(9-cyclopropyl-6-fluoro-7-(pyrazin-2-yl)isothiazolo...)
Show SMILES Fc1cc2c(cc1-c1cnccn1)n(C1CC1)c1s[nH]c(=O)c1c2=O
Show InChI InChI=1S/C17H11FN4O2S/c18-11-5-10-13(6-9(11)12-7-19-3-4-20-12)22(8-1-2-8)17-14(15(10)23)16(24)21-25-17/h3-8H,1-2H2,(H,21,24)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 6.40E+4n/an/an/an/an/an/a



Achillion Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4

Bioorg Med Chem Lett 16: 1277-81 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.064
BindingDB Entry DOI: 10.7270/Q26D5SKN
More data for this
Ligand-Target Pair