BDBM50179477 5-[1-[2-(4'-tert-Butyl-biphenyl-3-yl)-1H-benzoimidazol-5-yl]-methylidene]-2-thioxo-thiazolidin-4-one::CHEMBL382806

SMILES: CC(C)(C)c1ccc(cc1)-c1cccc(c1)-c1nc2ccc(C=C3SC(=S)NC3=O)cc2[nH]1

InChI Key: InChIKey=ZDLZBIIOVKVDFC-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50179477   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50179477 (5-[1-[2-(4'-tert-Butyl-biphenyl-3-yl)-1H-benzoimid...) Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(c1)-c1nc2ccc(C=C3SC(=S)NC3=O)cc2[nH]1 |w:22.23| Show InChI InChI=1S/C27H23N3OS2/c1-27(2,3)20-10-8-17(9-11-20)18-5-4-6-19(15-18)24-28-21-12-7-16(13-22(21)29-24)14-23-25(31)30-26(32)33-23/h4-15H,1-3H3,(H,28,29)(H,30,31,32)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	900	n/a	n/a	n/a	n/a
GlaxoSmithKline Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity as induced proliferation in Ba/F3-hTpoR murine lymphocyte expressing human TPOR				Bioorg Med Chem Lett 16: 1212-6 (2006) Article DOI: 10.1016/j.bmcl.2005.11.096 BindingDB Entry DOI: 10.7270/Q2V124BM
					More data for this Ligand-Target Pair