BDBM50181374 2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-piperidine)-1-ylpropyl]benzamide::CHEMBL202443

SMILES: O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1

InChI Key: InChIKey=KFXRFKRUMZXDFI-UHFFFAOYSA-N

Data: 5 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50181374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50181374 (2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...) Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1 Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells				J Med Chem 49: 847-9 (2006) Article DOI: 10.1021/jm0509851 BindingDB Entry DOI: 10.7270/Q2DJ5F78
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50181374 (2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...) Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1 Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cells				J Med Chem 49: 847-9 (2006) Article DOI: 10.1021/jm0509851 BindingDB Entry DOI: 10.7270/Q2DJ5F78
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50181374 (2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...) Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1 Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells				J Med Chem 49: 847-9 (2006) Article DOI: 10.1021/jm0509851 BindingDB Entry DOI: 10.7270/Q2DJ5F78
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50181374 (2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...) Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1 Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells				J Med Chem 49: 847-9 (2006) Article DOI: 10.1021/jm0509851 BindingDB Entry DOI: 10.7270/Q2DJ5F78
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50181374 (2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...) Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1 Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells				J Med Chem 49: 847-9 (2006) Article DOI: 10.1021/jm0509851 BindingDB Entry DOI: 10.7270/Q2DJ5F78
					More data for this Ligand-Target Pair
Nociceptin receptor (Homo sapiens (Human))	BDBM50181374 (2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...) Show SMILES O=C(NCCCN1CCC2(CCc3ccccc23)CC1)c1ccccc1Oc1ccccc1 Show InChI InChI=1S/C29H32N2O2/c32-28(25-12-5-7-14-27(25)33-24-10-2-1-3-11-24)30-19-8-20-31-21-17-29(18-22-31)16-15-23-9-4-6-13-26(23)29/h1-7,9-14H,8,15-22H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells				J Med Chem 49: 847-9 (2006) Article DOI: 10.1021/jm0509851 BindingDB Entry DOI: 10.7270/Q2DJ5F78
					More data for this Ligand-Target Pair