BDBM50181423 (2E)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl}propyl)-4-(4-methylphenyl)-4-oxobut-2-enamide::CHEMBL202401

SMILES: Cc1ccc(cc1)C(=O)\C=C\C(=O)NCCCN1CCC2(CCc3ccccc23)CC1

InChI Key: InChIKey=STMKLDNLUFXSTR-VAWYXSNFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50181423   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nociceptin receptor (Homo sapiens (Human))	BDBM50181423 ((2E)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine...) Show SMILES Cc1ccc(cc1)C(=O)\C=C\C(=O)NCCCN1CCC2(CCc3ccccc23)CC1 Show InChI InChI=1S/C27H32N2O2/c1-21-7-9-23(10-8-21)25(30)11-12-26(31)28-17-4-18-29-19-15-27(16-20-29)14-13-22-5-2-3-6-24(22)27/h2-3,5-12H,4,13-20H2,1H3,(H,28,31)/b12-11+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells				J Med Chem 49: 847-9 (2006) Article DOI: 10.1021/jm0509851 BindingDB Entry DOI: 10.7270/Q2DJ5F78
					More data for this Ligand-Target Pair