BDBM50181843 CHEMBL201414::cis-N-[(hexahydro-1H-pyrrolizin-l-yl)methyl]-2,3-dihydro-3-(1-methylethyl)-2-oxo-lH-benzimidazole-l-carboxamide

SMILES: CC(C)n1c2ccccc2n(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c1=O

InChI Key: InChIKey=QLKYHAQZBFWRHO-GJZGRUSLSA-N

Data: 2 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50181843   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HTR4 (GUINEA PIG)	BDBM50181843 (CHEMBL201414 | cis-N-[(hexahydro-1H-pyrrolizin-l-y...) Show SMILES CC(C)n1c2ccccc2n(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c1=O Show InChI InChI=1S/C19H26N4O2/c1-13(2)22-16-6-3-4-7-17(16)23(19(22)25)18(24)20-12-14-9-11-21-10-5-8-15(14)21/h3-4,6-7,13-15H,5,8-12H2,1-2H3,(H,20,24)/t14-,15-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum				J Med Chem 49: 1125-39 (2006) Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0
					More data for this Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT)	BDBM50181843 (CHEMBL201414 | cis-N-[(hexahydro-1H-pyrrolizin-l-y...) Show SMILES CC(C)n1c2ccccc2n(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c1=O Show InChI InChI=1S/C19H26N4O2/c1-13(2)22-16-6-3-4-7-17(16)23(19(22)25)18(24)20-12-14-9-11-21-10-5-8-15(14)21/h3-4,6-7,13-15H,5,8-12H2,1-2H3,(H,20,24)/t14-,15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar rat				J Med Chem 49: 1125-39 (2006) Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0
					More data for this Ligand-Target Pair
HTR4 (RAT)	BDBM50181843 (CHEMBL201414 | cis-N-[(hexahydro-1H-pyrrolizin-l-y...) Show SMILES CC(C)n1c2ccccc2n(C(=O)NC[C@@H]2CCN3CCC[C@@H]23)c1=O Show InChI InChI=1S/C19H26N4O2/c1-13(2)22-16-6-3-4-7-17(16)23(19(22)25)18(24)20-12-14-9-11-21-10-5-8-15(14)21/h3-4,6-7,13-15H,5,8-12H2,1-2H3,(H,20,24)/t14-,15-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	374	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonism at 5HT4 receptor in rat tunica muscularis mucosa				J Med Chem 49: 1125-39 (2006) Article DOI: 10.1021/jm0509501 BindingDB Entry DOI: 10.7270/Q2W096Q0
					More data for this Ligand-Target Pair