BDBM50182353 2-(3-(difluoromethyl)-5-(3-methyl-4-(thiazol-4-yl)phenyl)-1H-pyrazol-1-yl)-5-(methylsulfonyl)pyridine::CHEMBL380457

SMILES: Cc1cc(ccc1-c1cscn1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F

InChI Key: InChIKey=KHONPSMXBOXBPM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50182353   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclooxygenase-2 (Canis familiaris)	BDBM50182353 (2-(3-(difluoromethyl)-5-(3-methyl-4-(thiazol-4-yl)...) Show SMILES Cc1cc(ccc1-c1cscn1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C20H16F2N4O2S2/c1-12-7-13(3-5-15(12)17-10-29-11-24-17)18-8-16(20(21)22)25-26(18)19-6-4-14(9-23-19)30(2,27)28/h3-11,20H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Veterinary Medicine Research and Development Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of COX2 in canine whole blood				Bioorg Med Chem Lett 16: 2076-80 (2006) Article DOI: 10.1016/j.bmcl.2006.01.059 BindingDB Entry DOI: 10.7270/Q28K78PW
					More data for this Ligand-Target Pair
Cyclooxygenase-1 (Canis familiaris)	BDBM50182353 (2-(3-(difluoromethyl)-5-(3-methyl-4-(thiazol-4-yl)...) Show SMILES Cc1cc(ccc1-c1cscn1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C20H16F2N4O2S2/c1-12-7-13(3-5-15(12)17-10-29-11-24-17)18-8-16(20(21)22)25-26(18)19-6-4-14(9-23-19)30(2,27)28/h3-11,20H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Veterinary Medicine Research and Development Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of COX1 in canine whole blood				Bioorg Med Chem Lett 16: 2076-80 (2006) Article DOI: 10.1016/j.bmcl.2006.01.059 BindingDB Entry DOI: 10.7270/Q28K78PW
					More data for this Ligand-Target Pair