BDBM50182518 CHEMBL3819436::US9512121, 19

SMILES: Cn1cc(cn1)-c1cc(F)c2nnc(Sc3ccc4ncc5NC(=O)COc5c4c3)n2c1

InChI Key: InChIKey=ZTJLCACQNPNSHN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50182518   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50182518 (CHEMBL3819436 | US9512121, 19) Show SMILES Cn1cc(cn1)-c1cc(F)c2nnc(Sc3ccc4ncc5NC(=O)COc5c4c3)n2c1 Show InChI InChI=1S/C21H14FN7O2S/c1-28-8-12(6-24-28)11-4-15(22)20-26-27-21(29(20)9-11)32-13-2-3-16-14(5-13)19-17(7-23-16)25-18(30)10-31-19/h2-9H,10H2,1H3,(H,25,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
Southeast University Curated by ChEMBL					Assay Description Inhibition of c-Met (unknown origin) incubated for 1 hr by spectrophotometric analysis				Bioorg Med Chem 24: 3483-93 (2016) BindingDB Entry DOI: 10.7270/Q29G5PQT
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50182518 (CHEMBL3819436 | US9512121, 19) Show SMILES Cn1cc(cn1)-c1cc(F)c2nnc(Sc3ccc4ncc5NC(=O)COc5c4c3)n2c1 Show InChI InChI=1S/C21H14FN7O2S/c1-28-8-12(6-24-28)11-4-15(22)20-26-27-21(29(20)9-11)32-13-2-3-16-14(5-13)19-17(7-23-16)25-18(30)10-31-19/h2-9H,10H2,1H3,(H,25,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	20
Jiangsu Hansoh Pharmaceutical Co., Ltd. US Patent					Assay Description Experimental Purpose: The purpose is to study the effect of the compounds on c-MET tyrosine kinase activity at the molecular level. IC50 values were ...				US Patent US9512121 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NSV
					More data for this Ligand-Target Pair