BDBM50182691 CHEMBL383499::N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-4-(bis(1-methylethyl)amino)-2-butynamide

SMILES: CC(C)N(CC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1)C(C)C

InChI Key: InChIKey=QAWQPXUVEVTPDR-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50182691   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50182691 (CHEMBL383499 | N-[4-[(3-chloro-4-fluorophenyl)amin...) Show SMILES CC(C)N(CC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1)C(C)C Show InChI InChI=1S/C23H24ClFN6O/c1-14(2)31(15(3)4)9-5-6-22(32)30-21-11-17-20(12-26-21)27-13-28-23(17)29-16-7-8-19(25)18(24)10-16/h7-8,10-15H,9H2,1-4H3,(H,26,30,32)(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of erbB1 fusion protein expressed in baculovirus by ELISA				J Med Chem 49: 1475-85 (2006) Article DOI: 10.1021/jm050936o BindingDB Entry DOI: 10.7270/Q2ZS2X96
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50182691 (CHEMBL383499 | N-[4-[(3-chloro-4-fluorophenyl)amin...) Show SMILES CC(C)N(CC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1)C(C)C Show InChI InChI=1S/C23H24ClFN6O/c1-14(2)31(15(3)4)9-5-6-22(32)30-21-11-17-20(12-26-21)27-13-28-23(17)29-16-7-8-19(25)18(24)10-16/h7-8,10-15H,9H2,1-4H3,(H,26,30,32)(H,27,28,29)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of HER stimulated human erbB autophosphorylation in MDA-MB-453 cells				J Med Chem 49: 1475-85 (2006) Article DOI: 10.1021/jm050936o BindingDB Entry DOI: 10.7270/Q2ZS2X96
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50182691 (CHEMBL383499 | N-[4-[(3-chloro-4-fluorophenyl)amin...) Show SMILES CC(C)N(CC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1)C(C)C Show InChI InChI=1S/C23H24ClFN6O/c1-14(2)31(15(3)4)9-5-6-22(32)30-21-11-17-20(12-26-21)27-13-28-23(17)29-16-7-8-19(25)18(24)10-16/h7-8,10-15H,9H2,1-4H3,(H,26,30,32)(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of EGF stimulated human erbB1 autophosphorylation in NIH3T3 cells				J Med Chem 49: 1475-85 (2006) Article DOI: 10.1021/jm050936o BindingDB Entry DOI: 10.7270/Q2ZS2X96
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50182691 (CHEMBL383499 | N-[4-[(3-chloro-4-fluorophenyl)amin...) Show SMILES CC(C)N(CC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1)C(C)C Show InChI InChI=1S/C23H24ClFN6O/c1-14(2)31(15(3)4)9-5-6-22(32)30-21-11-17-20(12-26-21)27-13-28-23(17)29-16-7-8-19(25)18(24)10-16/h7-8,10-15H,9H2,1-4H3,(H,26,30,32)(H,27,28,29)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of erbB2 fusion protein expressed in baculovirus by ELISA				J Med Chem 49: 1475-85 (2006) Article DOI: 10.1021/jm050936o BindingDB Entry DOI: 10.7270/Q2ZS2X96
					More data for this Ligand-Target Pair
Receptor protein-tyrosine kinase erbB-4 (Homo sapiens (Human))	BDBM50182691 (CHEMBL383499 | N-[4-[(3-chloro-4-fluorophenyl)amin...) Show SMILES CC(C)N(CC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1)C(C)C Show InChI InChI=1S/C23H24ClFN6O/c1-14(2)31(15(3)4)9-5-6-22(32)30-21-11-17-20(12-26-21)27-13-28-23(17)29-16-7-8-19(25)18(24)10-16/h7-8,10-15H,9H2,1-4H3,(H,26,30,32)(H,27,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	538	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of erbB4 fusion protein expressed in baculovirus by ELISA				J Med Chem 49: 1475-85 (2006) Article DOI: 10.1021/jm050936o BindingDB Entry DOI: 10.7270/Q2ZS2X96
					More data for this Ligand-Target Pair