BindingDB PrimarySearch

BDBM50183539 CHEMBL381256::CHEMBL429492::trans-(R,R)-4-[2-[bis-(4-fluorophenyl)methoxy]ethyl]-1-(2-phenyl-cyclopropylmethyl)-piperidine oxalate

SMILES: Fc1ccc(cc1)C(OCCC1CCN(C[C@@H]2C[C@H]2c2ccccc2)CC1)c1ccc(F)cc1

InChI Key: InChIKey=OKMFPHWGPZHZKX-WNJJXGMVSA-N

Data: 5 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50183539
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50183539 (CHEMBL381256 \| CHEMBL429492 \| trans-(R,R)-4-[2-[bi...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NIDDK Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from DAT				J Med Chem 49: 1766-72 (2006) Article DOI: 10.1021/jm050766f BindingDB Entry DOI: 10.7270/Q2KS6R5F
NIDDK Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50183539 (CHEMBL381256 \| CHEMBL429492 \| trans-(R,R)-4-[2-[bi...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Heights Curated by ChEMBL					Assay Description Displacement of [125I]RTI55 from DAT in rat brain synaptosomes				Bioorg Med Chem 15: 1146-59 (2006) Article DOI: 10.1016/j.bmc.2006.09.070 BindingDB Entry DOI: 10.7270/Q2M61JXC
University Heights Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50183539 (CHEMBL381256 \| CHEMBL429492 \| trans-(R,R)-4-[2-[bi...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NIDDK Curated by ChEMBL					Assay Description Displacement of [125I]RTI-55 from SERT				J Med Chem 49: 1766-72 (2006) Article DOI: 10.1021/jm050766f BindingDB Entry DOI: 10.7270/Q2KS6R5F
NIDDK Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50183539 (CHEMBL381256 \| CHEMBL429492 \| trans-(R,R)-4-[2-[bi...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Heights Curated by ChEMBL					Assay Description Displacement of [125I]RTI55 from SERT in rat brain synaptosomes				Bioorg Med Chem 15: 1146-59 (2006) Article DOI: 10.1016/j.bmc.2006.09.070 BindingDB Entry DOI: 10.7270/Q2M61JXC
University Heights Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50183539 (CHEMBL381256 \| CHEMBL429492 \| trans-(R,R)-4-[2-[bi...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	947	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NIDDK Curated by ChEMBL					Assay Description Displacement of [3H]nisoxetine from NET				J Med Chem 49: 1766-72 (2006) Article DOI: 10.1021/jm050766f BindingDB Entry DOI: 10.7270/Q2KS6R5F
NIDDK Curated by ChEMBL					More data for this Ligand-Target Pair