Found 6 hits for monomerid = 50183724 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50183724
(CHEMBL207999 | N-(1-(3,3-dimethylbutanoyl)-4-(2-(h...)Show SMILES Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCN(CC2)C(=O)CC(C)(C)C)c2ccccc2n1 Show InChI InChI=1S/C31H38N4O5/c1-21-17-23(25-7-5-6-8-26(25)32-21)20-40-24-11-9-22(10-12-24)29(38)33-31(18-27(36)34-39)13-15-35(16-14-31)28(37)19-30(2,3)4/h5-12,17,39H,13-16,18-20H2,1-4H3,(H,33,38)(H,34,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >2.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Binding affinity to MMP9 |
Bioorg Med Chem Lett 16: 2699-704 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.015 BindingDB Entry DOI: 10.7270/Q2TB16H3 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50183724
(CHEMBL207999 | N-(1-(3,3-dimethylbutanoyl)-4-(2-(h...)Show SMILES Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCN(CC2)C(=O)CC(C)(C)C)c2ccccc2n1 Show InChI InChI=1S/C31H38N4O5/c1-21-17-23(25-7-5-6-8-26(25)32-21)20-40-24-11-9-22(10-12-24)29(38)33-31(18-27(36)34-39)13-15-35(16-14-31)28(37)19-30(2,3)4/h5-12,17,39H,13-16,18-20H2,1-4H3,(H,33,38)(H,34,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >3.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Binding affinity to MMP2 |
Bioorg Med Chem Lett 16: 2699-704 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.015 BindingDB Entry DOI: 10.7270/Q2TB16H3 |
More data for this Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50183724
(CHEMBL207999 | N-(1-(3,3-dimethylbutanoyl)-4-(2-(h...)Show SMILES Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCN(CC2)C(=O)CC(C)(C)C)c2ccccc2n1 Show InChI InChI=1S/C31H38N4O5/c1-21-17-23(25-7-5-6-8-26(25)32-21)20-40-24-11-9-22(10-12-24)29(38)33-31(18-27(36)34-39)13-15-35(16-14-31)28(37)19-30(2,3)4/h5-12,17,39H,13-16,18-20H2,1-4H3,(H,33,38)(H,34,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >4.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Binding affinity to MMP1 |
Bioorg Med Chem Lett 16: 2699-704 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.015 BindingDB Entry DOI: 10.7270/Q2TB16H3 |
More data for this Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50183724
(CHEMBL207999 | N-(1-(3,3-dimethylbutanoyl)-4-(2-(h...)Show SMILES Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCN(CC2)C(=O)CC(C)(C)C)c2ccccc2n1 Show InChI InChI=1S/C31H38N4O5/c1-21-17-23(25-7-5-6-8-26(25)32-21)20-40-24-11-9-22(10-12-24)29(38)33-31(18-27(36)34-39)13-15-35(16-14-31)28(37)19-30(2,3)4/h5-12,17,39H,13-16,18-20H2,1-4H3,(H,33,38)(H,34,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >5.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Binding affinity to MMP13 |
Bioorg Med Chem Lett 16: 2699-704 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.015 BindingDB Entry DOI: 10.7270/Q2TB16H3 |
More data for this Ligand-Target Pair | |
ADAM17
(Sus scrofa (pig)) | BDBM50183724
(CHEMBL207999 | N-(1-(3,3-dimethylbutanoyl)-4-(2-(h...)Show SMILES Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCN(CC2)C(=O)CC(C)(C)C)c2ccccc2n1 Show InChI InChI=1S/C31H38N4O5/c1-21-17-23(25-7-5-6-8-26(25)32-21)20-40-24-11-9-22(10-12-24)29(38)33-31(18-27(36)34-39)13-15-35(16-14-31)28(37)19-30(2,3)4/h5-12,17,39H,13-16,18-20H2,1-4H3,(H,33,38)(H,34,36) | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of porcine TACE |
Bioorg Med Chem Lett 16: 2699-704 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.015 BindingDB Entry DOI: 10.7270/Q2TB16H3 |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50183724
(CHEMBL207999 | N-(1-(3,3-dimethylbutanoyl)-4-(2-(h...)Show SMILES Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCN(CC2)C(=O)CC(C)(C)C)c2ccccc2n1 Show InChI InChI=1S/C31H38N4O5/c1-21-17-23(25-7-5-6-8-26(25)32-21)20-40-24-11-9-22(10-12-24)29(38)33-31(18-27(36)34-39)13-15-35(16-14-31)28(37)19-30(2,3)4/h5-12,17,39H,13-16,18-20H2,1-4H3,(H,33,38)(H,34,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 212 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of LPS-stimulated TNFalpha production in human whole blood |
Bioorg Med Chem Lett 16: 2699-704 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.015 BindingDB Entry DOI: 10.7270/Q2TB16H3 |
More data for this Ligand-Target Pair | |