BDBM50184105 4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{[(S)-(cyclopropylmethyl-carbamoyl)-phenyl-methyl]-carbamoyl}-3-ethoxy-phenyl)-amide::CHEMBL126377

SMILES: COc1cc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)ccc1C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1

InChI Key: InChIKey=AYAMQIMUPOXSKE-PMERELPUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50184105   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Microsomal triglyceride transfer protein (Homo sapiens (Human))	BDBM50184105 (4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...) Show SMILES COc1cc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)ccc1C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-19-25(39-31(41)27-10-6-5-9-26(27)22-13-15-24(16-14-22)34(35,36)37)17-18-28(29)32(42)40-30(23-7-3-2-4-8-23)33(43)38-20-21-11-12-21/h2-10,13-19,21,30H,11-12,20H2,1H3,(H,38,43)(H,39,41)(H,40,42)/t30-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.01	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of MTP in canine liver microsomes				Bioorg Med Chem Lett 16: 3039-42 (2006) Article DOI: 10.1016/j.bmcl.2006.02.058 BindingDB Entry DOI: 10.7270/Q2D21X68
					More data for this Ligand-Target Pair