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BDBM50184118 4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-methoxy-4-[((S)-phenyl-propylcarbamoyl-methyl)-carbamoyl]-phenyl}-amide::CHEMBL377951

SMILES: CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(OC)c1)c1ccccc1

InChI Key: InChIKey=MZBUXGBOIZHPQT-LJAQVGFWSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50184118   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Microsomal triglyceride transfer protein


(Homo sapiens (Human))		BDBM50184118
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...)
Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(OC)c1)c1ccccc1
Show InChI InChI=1S/C33H30F3N3O4/c1-3-19-37-32(42)29(22-9-5-4-6-10-22)39-30(40)23-15-18-27(28(20-23)43-2)38-31(41)26-12-8-7-11-25(26)21-13-16-24(17-14-21)33(34,35)36/h4-18,20,29H,3,19H2,1-2H3,(H,37,42)(H,38,41)(H,39,40)/t29-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes

Bioorg Med Chem Lett 16: 3039-42 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68
More data for this
Ligand-Target Pair