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BDBM50184137 4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{[(S)-(ethyl-propyl-carbamoyl)-phenyl-methyl]-carbamoyl}-2-methoxy-phenyl)-amide::CHEMBL380472

SMILES: CCCN(CC)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(OC)c1)c1ccccc1

InChI Key: InChIKey=ZYPFMALQWLHSNM-HKBQPEDESA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50184137   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Microsomal triglyceride transfer protein


(Homo sapiens (Human))		BDBM50184137
PNG
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Show SMILES CCCN(CC)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(OC)c1)c1ccccc1
Show InChI InChI=1S/C35H34F3N3O4/c1-4-21-41(5-2)34(44)31(24-11-7-6-8-12-24)40-32(42)25-17-20-29(30(22-25)45-3)39-33(43)28-14-10-9-13-27(28)23-15-18-26(19-16-23)35(36,37)38/h6-20,22,31H,4-5,21H2,1-3H3,(H,39,43)(H,40,42)/t31-/m0/s1
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Article
PubMed
n/an/a 2.34n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of MTP in canine liver microsomes

Bioorg Med Chem Lett 16: 3039-42 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68
More data for this
Ligand-Target Pair