Found 4 hits for monomerid = 50184471 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Insulin-like growth factor I receptor
(Homo sapiens (Human)) | BDBM50184471
(CHEMBL3822583)Show SMILES CC(=O)N1CCC(CC1)n1ncc(Nc2ncc(Cl)c(n2)-c2cnc3ccccn23)c1C Show InChI InChI=1S/C22H23ClN8O/c1-14-18(12-26-31(14)16-6-9-29(10-7-16)15(2)32)27-22-25-11-17(23)21(28-22)19-13-24-20-5-3-4-8-30(19)20/h3-5,8,11-13,16H,6-7,9-10H2,1-2H3,(H,25,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human IGF-1R using fluorescent labeled FL-KKSRGDYMTMQIG-CONH2 as substrate after 1 hr 50 mins |
J Med Chem 59: 4859-66 (2016)
BindingDB Entry DOI: 10.7270/Q2KS6TG9 |
More data for this Ligand-Target Pair | |
1,3-beta-glucan synthase component GLS2
(Saccharomyces cerevisiae) | BDBM50184471
(CHEMBL3822583)Show SMILES CC(=O)N1CCC(CC1)n1ncc(Nc2ncc(Cl)c(n2)-c2cnc3ccccn23)c1C Show InChI InChI=1S/C22H23ClN8O/c1-14-18(12-26-31(14)16-6-9-29(10-7-16)15(2)32)27-22-25-11-17(23)21(28-22)19-13-24-20-5-3-4-8-30(19)20/h3-5,8,11-13,16H,6-7,9-10H2,1-2H3,(H,25,27,28) | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human ERG expressed in CHOK1 cells after 6 mins by electrophysiology assay |
J Med Chem 59: 4859-66 (2016)
BindingDB Entry DOI: 10.7270/Q2KS6TG9 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor I receptor
(Homo sapiens (Human)) | BDBM50184471
(CHEMBL3822583)Show SMILES CC(=O)N1CCC(CC1)n1ncc(Nc2ncc(Cl)c(n2)-c2cnc3ccccn23)c1C Show InChI InChI=1S/C22H23ClN8O/c1-14-18(12-26-31(14)16-6-9-29(10-7-16)15(2)32)27-22-25-11-17(23)21(28-22)19-13-24-20-5-3-4-8-30(19)20/h3-5,8,11-13,16H,6-7,9-10H2,1-2H3,(H,25,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of IGF1-induced human IGF1R autophosphorylation expressed in IGF-1R knock-out mouse fibroblasts |
J Med Chem 59: 4859-66 (2016)
BindingDB Entry DOI: 10.7270/Q2KS6TG9 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50184471
(CHEMBL3822583)Show SMILES CC(=O)N1CCC(CC1)n1ncc(Nc2ncc(Cl)c(n2)-c2cnc3ccccn23)c1C Show InChI InChI=1S/C22H23ClN8O/c1-14-18(12-26-31(14)16-6-9-29(10-7-16)15(2)32)27-22-25-11-17(23)21(28-22)19-13-24-20-5-3-4-8-30(19)20/h3-5,8,11-13,16H,6-7,9-10H2,1-2H3,(H,25,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 232 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of CDK2 (unknown origin) |
J Med Chem 59: 4859-66 (2016)
BindingDB Entry DOI: 10.7270/Q2KS6TG9 |
More data for this Ligand-Target Pair | |