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SMILES: CC(C)(C)c1ccc(cc1)-c1nc2cc(ccc2[nH]1)-c1ncccc1C(F)(F)F

InChI Key: InChIKey=CZXZLJJJPXAZQU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50184742   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50184742
PNG
(2-(4-tert-butylphenyl)-6-(3-(trifluoromethyl)pyrid...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1nc2cc(ccc2[nH]1)-c1ncccc1C(F)(F)F
Show InChI InChI=1S/C23H20F3N3/c1-22(2,3)16-9-6-14(7-10-16)21-28-18-11-8-15(13-19(18)29-21)20-17(23(24,25)26)5-4-12-27-20/h4-13H,1-3H3,(H,28,29)
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n/an/a 224n/an/an/an/an/an/a



Merck Sharp & Dohme

Curated by ChEMBL


Assay Description
Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay

Bioorg Med Chem Lett 16: 2872-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.004
BindingDB Entry DOI: 10.7270/Q2959H50
More data for this
Ligand-Target Pair