BDBM50185045 CHEMBL383076::N-{2-[2-(3-(S)-hydroxypyrrolidin-1-yl)ethyl]-2H-indazol-5-yl}-N'-(4-phenoxyphenyl)urea

SMILES: O[C@H]1CCN(CCn2cc3cc(NC(=O)Nc4ccc(Oc5ccccc5)cc4)ccc3n2)C1

InChI Key: InChIKey=FKEHSKGAWARCKO-QFIPXVFZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50185045   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50185045 (CHEMBL383076 | N-{2-[2-(3-(S)-hydroxypyrrolidin-1-...) Show SMILES O[C@H]1CCN(CCn2cc3cc(NC(=O)Nc4ccc(Oc5ccccc5)cc4)ccc3n2)C1 Show InChI InChI=1S/C26H27N5O3/c32-22-12-13-30(18-22)14-15-31-17-19-16-21(8-11-25(19)29-31)28-26(33)27-20-6-9-24(10-7-20)34-23-4-2-1-3-5-23/h1-11,16-17,22,32H,12-15,18H2,(H2,27,28,33)/t22-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]-MCH from MCHr1 expressed in IMR32 (I3.4.2) cells				J Med Chem 49: 2339-52 (2006) Article DOI: 10.1021/jm0512286 BindingDB Entry DOI: 10.7270/Q24F1Q9F
					More data for this Ligand-Target Pair