BindingDB PrimarySearch

BDBM50185355 1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-carboxamide::1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxamide::CHEMBL204302

SMILES: CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(N)=O)cc1

InChI Key: InChIKey=YZCYTZMIWDBOHZ-UHFFFAOYSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50185355
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cPLA2 C2 (Homo sapiens (Human))	BDBM50185355 (1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of Münster Curated by ChEMBL					Assay Description Inhibition of human isolated cPLA2alpha by vescicle assay				J Med Chem 49: 2611-20 (2006) Article DOI: 10.1021/jm051243a BindingDB Entry DOI: 10.7270/Q2668CSF
University of Münster Curated by ChEMBL					More data for this Ligand-Target Pair
cPLA2 C2 (Homo sapiens (Human))	BDBM50185355 (1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
University of Münster Curated by ChEMBL					Assay Description Inhibition of cPLA2alpha activity assessed by A23187-induced arachidonic acid release in human platelet				J Med Chem 49: 2611-20 (2006) Article DOI: 10.1021/jm051243a BindingDB Entry DOI: 10.7270/Q2668CSF
University of Münster Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50185355 (1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of FAAH from rat brain microsomes by RP-HPLC				Bioorg Med Chem 18: 945-52 (2010) Article DOI: 10.1016/j.bmc.2009.11.028 BindingDB Entry DOI: 10.7270/Q2N016MF
University of M£nster Curated by ChEMBL					More data for this Ligand-Target Pair
cPLA2 C2 (Homo sapiens (Human))	BDBM50185355 (1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of M£nster Curated by ChEMBL					Assay Description Inhibition of cPLA2 from human platelets by RP-HPLC				Bioorg Med Chem 18: 945-52 (2010) Article DOI: 10.1016/j.bmc.2009.11.028 BindingDB Entry DOI: 10.7270/Q2N016MF
University of M£nster Curated by ChEMBL					More data for this Ligand-Target Pair
cPLA2 C2 (Homo sapiens (Human))	BDBM50185355 (1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
University of Münster Curated by ChEMBL					Assay Description Inhibition of human platelet cPLA2-alpha assessed as arachidonic acid release by vesicle assay				Bioorg Med Chem 15: 2883-91 (2007) Article DOI: 10.1016/j.bmc.2007.02.016 BindingDB Entry DOI: 10.7270/Q24749JP
University of Münster Curated by ChEMBL					More data for this Ligand-Target Pair