BDBM50186557 1-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimidin-4-yl)-1-methyl-3-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)urea::CHEMBL378410
SMILES: CCN(CC)CCOc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1
InChI Key: InChIKey=NPBPPTPGWGVYGV-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50186557 (1-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of Lck | Bioorg Med Chem Lett 16: 3646-50 (2006) Article DOI: 10.1016/j.bmcl.2006.04.072 BindingDB Entry DOI: 10.7270/Q2GF0T45 | |||||||||||
More data for this Ligand-Target Pair |