BDBM50186560 1-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimidin-4-yl)-3-(5-hydroxy-2-methylphenyl)-1-methylurea::CHEMBL206873

SMILES: CCN(CC)CCOc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(O)ccc2C)cc1

InChI Key: InChIKey=VNPXFMWIZAHZML-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50186560   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50186560 (1-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimi...) Show SMILES CCN(CC)CCOc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(O)ccc2C)cc1 Show InChI InChI=1S/C25H32N6O3/c1-5-31(6-2)13-14-34-21-11-8-19(9-12-21)28-23-16-24(27-17-26-23)30(4)25(33)29-22-15-20(32)10-7-18(22)3/h7-12,15-17,32H,5-6,13-14H2,1-4H3,(H,29,33)(H,26,27,28)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Procter & Gamble Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Lck				Bioorg Med Chem Lett 16: 3646-50 (2006) Article DOI: 10.1016/j.bmcl.2006.04.072 BindingDB Entry DOI: 10.7270/Q2GF0T45
					More data for this Ligand-Target Pair