BDBM50186788 2-{[4-(3'-cyano-biphenyl-4-yl)-1-cyclopentyl-piperidin-4-yl]-methyl-amino}-N-(3,5-dichloro-phenyl)-acetamide::CHEMBL379489
SMILES: CN(CC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F)C1(CCN(CC1)C1CCCC1)c1ccc(cc1)-c1cccc(c1)C#N
InChI Key: InChIKey=GEIBEOSSYAMBAM-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Melanin-concentrating hormone receptor (Homo sapiens (Human)) | BDBM50186788 (2-{[4-(3'-cyano-biphenyl-4-yl)-1-cyclopentyl-piper...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute Curated by ChEMBL | Assay Description Binding affinity at human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assay | Bioorg Med Chem Lett 16: 3668-73 (2006) Article DOI: 10.1016/j.bmcl.2006.04.061 BindingDB Entry DOI: 10.7270/Q2251HT9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GPR145 (Homo sapiens (Human)) | BDBM50186788 (2-{[4-(3'-cyano-biphenyl-4-yl)-1-cyclopentyl-piper...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute Curated by ChEMBL | Assay Description Binding affinity at human MCHR2 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assay | Bioorg Med Chem Lett 16: 3668-73 (2006) Article DOI: 10.1016/j.bmcl.2006.04.061 BindingDB Entry DOI: 10.7270/Q2251HT9 | |||||||||||
More data for this Ligand-Target Pair |