BDBM50186823 4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-[1-(thiophene-2-carbonyl)-piperidin-4-ylidene]-methyl}-biphenyl-3-carbonitrile::CHEMBL377864

SMILES: Fc1cc2[nH]c(nc2cc1C(F)(F)F)C(=C1CCN(CC1)C(=O)c1cccs1)c1ccc(cc1)-c1cccc(c1)C#N

InChI Key: InChIKey=PEBKTIURWUXCGV-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50186823   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50186823 (4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...) Show SMILES Fc1cc2[nH]c(nc2cc1C(F)(F)F)C(=C1CCN(CC1)C(=O)c1cccs1)c1ccc(cc1)-c1cccc(c1)C#N |(26.9,-17.52,;26.14,-18.86,;24.61,-18.86,;23.84,-20.19,;22.34,-20.51,;22.18,-22.04,;23.59,-22.66,;24.61,-21.52,;26.14,-21.52,;26.91,-20.19,;28.45,-20.19,;29.99,-20.19,;28.45,-21.73,;28.45,-18.65,;20.85,-22.81,;20.85,-24.35,;19.51,-25.11,;19.51,-26.65,;20.84,-27.42,;22.18,-26.65,;22.18,-25.11,;20.84,-28.96,;22.17,-29.73,;19.5,-29.73,;18.1,-29.1,;17.07,-30.25,;17.83,-31.58,;19.34,-31.27,;19.51,-22.04,;18.17,-22.81,;16.84,-22.04,;16.84,-20.5,;18.17,-19.73,;19.51,-20.49,;15.51,-19.73,;14.19,-20.5,;12.85,-19.74,;12.85,-18.19,;14.18,-17.42,;15.51,-18.19,;14.17,-15.88,;14.17,-14.34,)| Show InChI InChI=1S/C32H22F4N4OS/c33-25-17-27-26(16-24(25)32(34,35)36)38-30(39-27)29(22-10-12-40(13-11-22)31(41)28-5-2-14-42-28)21-8-6-20(7-9-21)23-4-1-3-19(15-23)18-37/h1-9,14-17H,10-13H2,(H,38,39)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assay				Bioorg Med Chem Lett 16: 3674-8 (2006) Article DOI: 10.1016/j.bmcl.2006.04.062 BindingDB Entry DOI: 10.7270/Q2XG9QQB
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50186823 (4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...) Show SMILES Fc1cc2[nH]c(nc2cc1C(F)(F)F)C(=C1CCN(CC1)C(=O)c1cccs1)c1ccc(cc1)-c1cccc(c1)C#N |(26.9,-17.52,;26.14,-18.86,;24.61,-18.86,;23.84,-20.19,;22.34,-20.51,;22.18,-22.04,;23.59,-22.66,;24.61,-21.52,;26.14,-21.52,;26.91,-20.19,;28.45,-20.19,;29.99,-20.19,;28.45,-21.73,;28.45,-18.65,;20.85,-22.81,;20.85,-24.35,;19.51,-25.11,;19.51,-26.65,;20.84,-27.42,;22.18,-26.65,;22.18,-25.11,;20.84,-28.96,;22.17,-29.73,;19.5,-29.73,;18.1,-29.1,;17.07,-30.25,;17.83,-31.58,;19.34,-31.27,;19.51,-22.04,;18.17,-22.81,;16.84,-22.04,;16.84,-20.5,;18.17,-19.73,;19.51,-20.49,;15.51,-19.73,;14.19,-20.5,;12.85,-19.74,;12.85,-18.19,;14.18,-17.42,;15.51,-18.19,;14.17,-15.88,;14.17,-14.34,)| Show InChI InChI=1S/C32H22F4N4OS/c33-25-17-27-26(16-24(25)32(34,35)36)38-30(39-27)29(22-10-12-40(13-11-22)31(41)28-5-2-14-42-28)21-8-6-20(7-9-21)23-4-1-3-19(15-23)18-37/h1-9,14-17H,10-13H2,(H,38,39)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
University of Science and Technology Curated by ChEMBL					Assay Description Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay				Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126741
					More data for this Ligand-Target Pair