BDBM50186830 4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5,6-dichloro-1H-benzoimidazol-2-yl)-methyl]-biphenyl-3-carbonitrile::CHEMBL211820

SMILES: Clc1cc2nc([nH]c2cc1Cl)C(=C1CCN(CC2CC2)CC1)c1ccc(cc1)-c1cccc(c1)C#N

InChI Key: InChIKey=MKNULTWZJGMRFO-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50186830   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM50186830 (4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5,6...) Show SMILES Clc1cc2nc([nH]c2cc1Cl)C(=C1CCN(CC2CC2)CC1)c1ccc(cc1)-c1cccc(c1)C#N |(7.77,-.56,;6.23,-.56,;5.46,-1.89,;3.93,-1.89,;2.91,-3.04,;1.5,-2.41,;1.66,-.88,;3.17,-.56,;3.93,.77,;5.46,.77,;6.23,2.1,;.17,-3.18,;.17,-4.72,;-1.16,-5.48,;-1.17,-7.02,;.17,-7.79,;.16,-9.33,;-1.17,-10.1,;-2.71,-10.1,;-1.94,-11.44,;1.5,-7.02,;1.51,-5.48,;-1.16,-2.41,;-2.5,-3.19,;-3.83,-2.42,;-3.83,-.87,;-2.5,-.1,;-1.17,-.87,;-5.16,-.1,;-6.49,-.87,;-7.82,-.11,;-7.83,1.44,;-6.49,2.21,;-5.16,1.44,;-6.49,3.75,;-6.49,5.29,)| Show InChI InChI=1S/C30H26Cl2N4/c31-25-15-27-28(16-26(25)32)35-30(34-27)29(23-10-12-36(13-11-23)18-19-4-5-19)22-8-6-21(7-9-22)24-3-1-2-20(14-24)17-33/h1-3,6-9,14-16,19H,4-5,10-13,18H2,(H,34,35)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assay				Bioorg Med Chem Lett 16: 3674-8 (2006) Article DOI: 10.1016/j.bmcl.2006.04.062 BindingDB Entry DOI: 10.7270/Q2XG9QQB
					More data for this Ligand-Target Pair