BDBM50187614 3-trifluoromethyl-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide::CHEMBL210573

SMILES: FC(F)(F)c1cccc(c1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1

InChI Key: InChIKey=FIZSVTZLILCHQS-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50187614   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50187614 (3-trifluoromethyl-N-(1,3-diphenyl-1H-pyrazol-5-yl)...) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H16F3N3O/c24-23(25,26)18-11-7-10-17(14-18)22(30)27-21-15-20(16-8-3-1-4-9-16)28-29(21)19-12-5-2-6-13-19/h1-15H,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.65E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in HEK293 cells				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50187614 (3-trifluoromethyl-N-(1,3-diphenyl-1H-pyrazol-5-yl)...) Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H16F3N3O/c24-23(25,26)18-11-7-10-17(14-18)22(30)27-21-15-20(16-8-3-1-4-9-16)28-29(21)19-12-5-2-6-13-19/h1-15H,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	228	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair