BDBM50187657 3,6-dihydroxy-2-phenyl-4H-chromen-4-one::3,6-dihydroxy-flavone::3,6-dihydroxyflavone::CHEMBL210411

SMILES: Oc1ccc2oc(-c3ccccc3)c(O)c(=O)c2c1

InChI Key: InChIKey=XHLOLFKZCUCROE-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50187657   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase III (Homo sapiens (Human))	BDBM50187657 (3,6-dihydroxy-2-phenyl-4H-chromen-4-one | 3,6-dihy...) Show SMILES Oc1ccc2oc(-c3ccccc3)c(O)c(=O)c2c1 Show InChI InChI=1S/C15H10O4/c16-10-6-7-12-11(8-10)13(17)14(18)15(19-12)9-4-2-1-3-5-9/h1-8,16,18H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.64E+4	n/a	n/a	n/a	n/a	7.4	37
Josip Juraj Strossmayer University of Osijek					Assay Description The inhibitory activity of flavonoids toward human DPP III was assayed in a 50 mM Tris-HCl buffer, pH 7.4. In brief, recombinant human DPP III (0.29 ...				Chem Biol Drug Des 89: 619-627 (2017) Article DOI: 10.1111/cbdd.12887 BindingDB Entry DOI: 10.7270/Q2X34WBS
					More data for this Ligand-Target Pair
15-Lipoxygenase-2 (15-LOX-2) (Homo sapiens (Human))	BDBM50187657 (3,6-dihydroxy-2-phenyl-4H-chromen-4-one | 3,6-dihy...) Show SMILES Oc1ccc2oc(-c3ccccc3)c(O)c(=O)c2c1 Show InChI InChI=1S/C15H10O4/c16-10-6-7-12-11(8-10)13(17)14(18)15(19-12)9-4-2-1-3-5-9/h1-8,16,18H	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Santiago de Chile Curated by ChEMBL					Assay Description Inhibition of 15-hLO2				Bioorg Med Chem 15: 7408-25 (2007) Article DOI: 10.1016/j.bmc.2007.07.036 BindingDB Entry DOI: 10.7270/Q2RN37KN
					More data for this Ligand-Target Pair
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase (Oryctolagus cuniculus)	BDBM50187657 (3,6-dihydroxy-2-phenyl-4H-chromen-4-one | 3,6-dihy...) Show SMILES Oc1ccc2oc(-c3ccccc3)c(O)c(=O)c2c1 Show InChI InChI=1S/C15H10O4/c16-10-6-7-12-11(8-10)13(17)14(18)15(19-12)9-4-2-1-3-5-9/h1-8,16,18H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Chemistry and Technology Prague Curated by ChEMBL					Assay Description Inhibition of rabbit skeletal muscle microsomes SERCA1a preincubated for 10 mins followed by addition of ATP and measured after 40 mins				J Med Chem 63: 1937-1963 (2020) Article DOI: 10.1021/acs.jmedchem.9b01509
					More data for this Ligand-Target Pair
12-Lipoxygenase (12-LOX) (Homo sapiens (Human))	BDBM50187657 (3,6-dihydroxy-2-phenyl-4H-chromen-4-one | 3,6-dihy...) Show SMILES Oc1ccc2oc(-c3ccccc3)c(O)c(=O)c2c1 Show InChI InChI=1S/C15H10O4/c16-10-6-7-12-11(8-10)13(17)14(18)15(19-12)9-4-2-1-3-5-9/h1-8,16,18H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Santiago de Chile Curated by ChEMBL					Assay Description Inhibition of 12-hLO				Bioorg Med Chem 15: 7408-25 (2007) Article DOI: 10.1016/j.bmc.2007.07.036 BindingDB Entry DOI: 10.7270/Q2RN37KN
					More data for this Ligand-Target Pair
Arachidonate 15-lipoxygenase (Homo sapiens (Human))	BDBM50187657 (3,6-dihydroxy-2-phenyl-4H-chromen-4-one | 3,6-dihy...) Show SMILES Oc1ccc2oc(-c3ccccc3)c(O)c(=O)c2c1 Show InChI InChI=1S/C15H10O4/c16-10-6-7-12-11(8-10)13(17)14(18)15(19-12)9-4-2-1-3-5-9/h1-8,16,18H	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Santiago de Chile Curated by ChEMBL					Assay Description Inhibition of 15-hLO1				Bioorg Med Chem 15: 7408-25 (2007) Article DOI: 10.1016/j.bmc.2007.07.036 BindingDB Entry DOI: 10.7270/Q2RN37KN
					More data for this Ligand-Target Pair