BDBM50188376 8-(2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL211373
SMILES: OC1(CCCCC1N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccccc1
InChI Key: InChIKey=BONFVDJOYDFOEN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Glycine transporter 2 (Homo sapiens (Human)) | BDBM50188376 (8-(2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-t...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.20E+4 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake at human GlyT2 by radiometric assay | Bioorg Med Chem Lett 16: 4311-5 (2006) Article DOI: 10.1016/j.bmcl.2006.05.058 BindingDB Entry DOI: 10.7270/Q2Z31Z8W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM50188376 (8-(2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-t...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]NOP from human NOP receptors expressed in HEK293 cells | Bioorg Med Chem Lett 16: 4311-5 (2006) Article DOI: 10.1016/j.bmcl.2006.05.058 BindingDB Entry DOI: 10.7270/Q2Z31Z8W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50188376 (8-(2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-t...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]naloxone from human mu opioid receptor expressed in BHK cells | Bioorg Med Chem Lett 16: 4311-5 (2006) Article DOI: 10.1016/j.bmcl.2006.05.058 BindingDB Entry DOI: 10.7270/Q2Z31Z8W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycine transporter 1 (Homo sapiens (Human)) | BDBM50188376 (8-(2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-t...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 44 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assay | Bioorg Med Chem Lett 16: 4311-5 (2006) Article DOI: 10.1016/j.bmcl.2006.05.058 BindingDB Entry DOI: 10.7270/Q2Z31Z8W | |||||||||||
More data for this Ligand-Target Pair |