BDBM50188859 CHEMBL378665::rac-4-(4-fluoro-phenyl)-8-(1-o-tolyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one
SMILES: Cc1ccccc1C1(CCCCC1)N1CCC2(CC1)C(CNC2=O)c1ccc(F)cc1
InChI Key: InChIKey=HQSPTAIHUHMQIB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Glycine transporter 2 (Homo sapiens (Human)) | BDBM50188859 (CHEMBL378665 | rac-4-(4-fluoro-phenyl)-8-(1-o-toly...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake at GlyT2 | Bioorg Med Chem Lett 16: 4321-5 (2006) Article DOI: 10.1016/j.bmcl.2006.05.063 BindingDB Entry DOI: 10.7270/Q2P26ZXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM50188859 (CHEMBL378665 | rac-4-(4-fluoro-phenyl)-8-(1-o-toly...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]NOP from human NOP receptor expressed in HEK293 cells | Bioorg Med Chem Lett 16: 4321-5 (2006) Article DOI: 10.1016/j.bmcl.2006.05.063 BindingDB Entry DOI: 10.7270/Q2P26ZXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycine transporter 1 (Homo sapiens (Human)) | BDBM50188859 (CHEMBL378665 | rac-4-(4-fluoro-phenyl)-8-(1-o-toly...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 350 | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]glycine uptake at GlyT1 | Bioorg Med Chem Lett 16: 4321-5 (2006) Article DOI: 10.1016/j.bmcl.2006.05.063 BindingDB Entry DOI: 10.7270/Q2P26ZXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50188859 (CHEMBL378665 | rac-4-(4-fluoro-phenyl)-8-(1-o-toly...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]naloxone from mu opioid receptor expressed in BHK cells | Bioorg Med Chem Lett 16: 4321-5 (2006) Article DOI: 10.1016/j.bmcl.2006.05.063 BindingDB Entry DOI: 10.7270/Q2P26ZXG | |||||||||||
More data for this Ligand-Target Pair |