BDBM50189114 CHEMBL265367::N-(4-(3-fluorobenzyloxy)-3-(trifluoromethyl)phenyl)-6-(5-((2-(1-methyl-1H-imidazol-2-ylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4-amine

SMILES: Cn1ccnc1S(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(c3)C(F)(F)F)c2c1

InChI Key: InChIKey=AZDCMGDGNHSVCZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50189114   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50189114 (CHEMBL265367 | N-(4-(3-fluorobenzyloxy)-3-(trifluo...) Show SMILES Cn1ccnc1S(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(c3)C(F)(F)F)c2c1 Show InChI InChI=1S/C33H28F4N6O4S/c1-43-13-11-39-32(43)48(44,45)14-12-38-18-25-7-10-29(47-25)22-5-8-28-26(16-22)31(41-20-40-28)42-24-6-9-30(27(17-24)33(35,36)37)46-19-21-3-2-4-23(34)15-21/h2-11,13,15-17,20,38H,12,14,18-19H2,1H3,(H,40,41,42)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of ErbB2				Bioorg Med Chem Lett 16: 4686-91 (2006) Article DOI: 10.1016/j.bmcl.2006.05.090 BindingDB Entry DOI: 10.7270/Q2VM4D2Z
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50189114 (CHEMBL265367 | N-(4-(3-fluorobenzyloxy)-3-(trifluo...) Show SMILES Cn1ccnc1S(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(c3)C(F)(F)F)c2c1 Show InChI InChI=1S/C33H28F4N6O4S/c1-43-13-11-39-32(43)48(44,45)14-12-38-18-25-7-10-29(47-25)22-5-8-28-26(16-22)31(41-20-40-28)42-24-6-9-30(27(17-24)33(35,36)37)46-19-21-3-2-4-23(34)15-21/h2-11,13,15-17,20,38H,12,14,18-19H2,1H3,(H,40,41,42)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of ErbB1				Bioorg Med Chem Lett 16: 4686-91 (2006) Article DOI: 10.1016/j.bmcl.2006.05.090 BindingDB Entry DOI: 10.7270/Q2VM4D2Z
					More data for this Ligand-Target Pair