BDBM50189576 (R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3-yl)-2-(4-(trifluoromethyl)phenyl)thieno[2,3-d]pyridazin-7(6H)-one::CHEMBL377241

SMILES: CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=VKAMBSPXFFZIQB-QGZVFWFLSA-N

Data: 3 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50189576   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GPR24 (RAT)	BDBM50189576 ((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...) Show SMILES CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H20F3N5OS/c1-27-17-8-9-30(13-17)20-7-6-18(12-28-20)31-22(32)21-15(11-29-31)10-19(33-21)14-2-4-16(5-3-14)23(24,25)26/h2-7,10-12,17,27H,8-9,13H2,1H3/t17-/m1/s1	Reactome pathway KEGG GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cells				J Med Chem 49: 3753-6 (2006) Article DOI: 10.1021/jm051263c BindingDB Entry DOI: 10.7270/Q2Z037SN
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50189576 ((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...) Show SMILES CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H20F3N5OS/c1-27-17-8-9-30(13-17)20-7-6-18(12-28-20)31-22(32)21-15(11-29-31)10-19(33-21)14-2-4-16(5-3-14)23(24,25)26/h2-7,10-12,17,27H,8-9,13H2,1H3/t17-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity to muscarinic M3R				J Med Chem 49: 3753-6 (2006) Article DOI: 10.1021/jm051263c BindingDB Entry DOI: 10.7270/Q2Z037SN
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50189576 ((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...) Show SMILES CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H20F3N5OS/c1-27-17-8-9-30(13-17)20-7-6-18(12-28-20)31-22(32)21-15(11-29-31)10-19(33-21)14-2-4-16(5-3-14)23(24,25)26/h2-7,10-12,17,27H,8-9,13H2,1H3/t17-/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity to muscarinic M1R				J Med Chem 49: 3753-6 (2006) Article DOI: 10.1021/jm051263c BindingDB Entry DOI: 10.7270/Q2Z037SN
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50189576 ((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...) Show SMILES CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H20F3N5OS/c1-27-17-8-9-30(13-17)20-7-6-18(12-28-20)31-22(32)21-15(11-29-31)10-19(33-21)14-2-4-16(5-3-14)23(24,25)26/h2-7,10-12,17,27H,8-9,13H2,1H3/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Affinity for human ERG channel by patch clamp assay				J Med Chem 49: 3753-6 (2006) Article DOI: 10.1021/jm051263c BindingDB Entry DOI: 10.7270/Q2Z037SN
					More data for this Ligand-Target Pair
GPR24 (RAT)	BDBM50189576 ((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...) Show SMILES CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H20F3N5OS/c1-27-17-8-9-30(13-17)20-7-6-18(12-28-20)31-22(32)21-15(11-29-31)10-19(33-21)14-2-4-16(5-3-14)23(24,25)26/h2-7,10-12,17,27H,8-9,13H2,1H3/t17-/m1/s1	Reactome pathway KEGG GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Activity at chimeric rat/human MCH1R by accumulation of GTPgammaS				J Med Chem 49: 3753-6 (2006) Article DOI: 10.1021/jm051263c BindingDB Entry DOI: 10.7270/Q2Z037SN
					More data for this Ligand-Target Pair