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BDBM50189603 CHEMBL377734::N-cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide

SMILES: Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1

InChI Key: InChIKey=CUPLTRAPYIXFAX-UHFFFAOYSA-N

Data: 27 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50189603   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of GSK3


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of JAK3


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of AKT


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>4.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a 40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FLK1


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of p38


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CaMK2


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Lck


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a 400n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a 1.66E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in HEK293 cells


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Her1


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Src


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Itk


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>4.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PKCzeta


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Her2


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MEK


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a 200n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PDGFR beta


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CDK2


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>4.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a 370n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of c-kit


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MAPKAPK2


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a 23n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FLK1


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of SRPK1


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Syk


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (Human))
BDBM50189603
PNG
(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Show SMILES Fc1cc(F)c(cc1NCc1cnc(Nc2ccccn2)s1)C(=O)NC1CC1
Show InChI InChI=1S/C19H17F2N5OS/c20-14-8-15(21)16(7-13(14)18(27)25-11-4-5-11)23-9-12-10-24-19(28-12)26-17-3-1-2-6-22-17/h1-3,6-8,10-11,23H,4-5,9H2,(H,25,27)(H,22,24,26)
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n/an/a>4.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of PKCeta


J Med Chem 49: 3766-9 (2006)


Article DOI: 10.1021/jm060347y
BindingDB Entry DOI: 10.7270/Q2PG1RBM
More data for this
Ligand-Target Pair