BDBM50189801 CHEMBL3827443

SMILES: CC(Oc1ccc2[nH]nc(-c3nc4c(cccc4[nH]3)N3CCCCC3)c2c1)c1c(Cl)cncc1Cl

InChI Key: InChIKey=NCNCLPFEZAIABU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50189801   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50189801 (CHEMBL3827443) Show SMILES CC(Oc1ccc2[nH]nc(-c3nc4c(cccc4[nH]3)N3CCCCC3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C26H24Cl2N6O/c1-15(23-18(27)13-29-14-19(23)28)35-16-8-9-20-17(12-16)24(33-32-20)26-30-21-6-5-7-22(25(21)31-26)34-10-3-2-4-11-34/h5-9,12-15H,2-4,10-11H2,1H3,(H,30,31)(H,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science& Technology Curated by ChEMBL					Assay Description Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA				J Med Chem 59: 6690-708 (2016) BindingDB Entry DOI: 10.7270/Q2474CT3
					More data for this Ligand-Target Pair