BDBM50189845 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine::CHEMBL212631

SMILES: COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1

InChI Key: InChIKey=QGLGNPCWSBQHAU-UHFFFAOYSA-N

Data: 11 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50189845   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Palack£ University Curated by ChEMBL					Assay Description Agonist activity at dopamine D4 receptor (unknown origin)				Eur J Med Chem 181: (2019) Article DOI: 10.1016/j.ejmech.2019.111569
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Palack£ University Curated by ChEMBL					Assay Description Agonist activity at dopamine D4 receptor (unknown origin)				Eur J Med Chem 181: (2019) Article DOI: 10.1016/j.ejmech.2019.111569
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoire de Chimie Th�rapeutique Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane				J Med Chem 49: 3938-47 (2006) Article DOI: 10.1021/jm060166w BindingDB Entry DOI: 10.7270/Q20G3KZ5
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoire de Chimie Th�rapeutique Curated by ChEMBL					Assay Description Displacement of [3H]7-OH-DPAT from human dopamine receptor D2(long) in CHO cell membrane				J Med Chem 49: 3938-47 (2006) Article DOI: 10.1021/jm060166w BindingDB Entry DOI: 10.7270/Q20G3KZ5
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoire de Chimie Th�rapeutique Curated by ChEMBL					Assay Description Displacement of [3H]7-OH-DPAT from porcine dopamine receptor D2				J Med Chem 49: 3938-47 (2006) Article DOI: 10.1021/jm060166w BindingDB Entry DOI: 10.7270/Q20G3KZ5
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	930	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoire de Chimie Th�rapeutique Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane				J Med Chem 49: 3938-47 (2006) Article DOI: 10.1021/jm060166w BindingDB Entry DOI: 10.7270/Q20G3KZ5
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	990	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoire de Chimie Th�rapeutique Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane				J Med Chem 49: 3938-47 (2006) Article DOI: 10.1021/jm060166w BindingDB Entry DOI: 10.7270/Q20G3KZ5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoire de Chimie Th�rapeutique Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor in porcine cortical membrane				J Med Chem 49: 3938-47 (2006) Article DOI: 10.1021/jm060166w BindingDB Entry DOI: 10.7270/Q20G3KZ5
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoire de Chimie Th�rapeutique Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane				J Med Chem 49: 3938-47 (2006) Article DOI: 10.1021/jm060166w BindingDB Entry DOI: 10.7270/Q20G3KZ5
					More data for this Ligand-Target Pair
5-HT2 (PIG)	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoire de Chimie Th�rapeutique Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from 5HT2 receptor in porcine cortical membrane				J Med Chem 49: 3938-47 (2006) Article DOI: 10.1021/jm060166w BindingDB Entry DOI: 10.7270/Q20G3KZ5
					More data for this Ligand-Target Pair
Dopamine D1 receptor (Sus scrofa)	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Laboratoire de Chimie Th�rapeutique Curated by ChEMBL					Assay Description Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane				J Med Chem 49: 3938-47 (2006) Article DOI: 10.1021/jm060166w BindingDB Entry DOI: 10.7270/Q20G3KZ5
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Laboratoire de Chimie Th�rapeutique Curated by ChEMBL					Assay Description Activity at human D4.2 receptor assessed as [3H]thymidine incorporation in CHO 10001 cells by mitogenesis assay				J Med Chem 49: 3938-47 (2006) Article DOI: 10.1021/jm060166w BindingDB Entry DOI: 10.7270/Q20G3KZ5
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50189845 (2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...) Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1 Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a
Laboratoire de Chimie Th�rapeutique Curated by ChEMBL					Assay Description Activity at human D4.4 receptor expressed in CHOK1 cells assessed as stimulation of [35S]GTP-gammaS binding				J Med Chem 49: 3938-47 (2006) Article DOI: 10.1021/jm060166w BindingDB Entry DOI: 10.7270/Q20G3KZ5
					More data for this Ligand-Target Pair